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Pathology Residency

Research in Digital Pathology and Artificial Intelligence

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Research in Digital Pathology and Artificial Intelligence

The Department of Pathology and Laboratory Medicine at Brown University is actively engaged in research across both Anatomic Pathology (AP) and Clinical Pathology (CP) at the intersection of digital pathology, artificial intelligence, and clinical informatics. Building on a rapidly expanding whole slide imaging and informatics infrastructure, our work spans both Anatomic Pathology and Clinical Pathology with a focus on clinically meaningful applications.

Current research efforts include the development and validation of computational pathology and machine learning methods for histopathology and cytopathology, quantitative image analysis, and the integration of digital pathology with molecular and clinical data. Projects emphasize rigorous validation, interpretability, and real-world workflow integration, with the goal of advancing diagnostic accuracy, efficiency, and education.

Residents and fellows have opportunities to participate in digital pathology and AI-focused research through mentored projects, dedicated research tracks, and collaborations across pathology, biomedical informatics, engineering, and data science at Brown. Trainees interested in careers that bridge pathology, technology, and innovation are encouraged to engage in these efforts.

Research articles

  • Histopathology-only Artificial Intelligence for Prostate Cancer: Towards Accessible Risk Stratification (2026)
  • Novel Computational Pipeline Enables Reliable Diagnosis of Inverted Urothelial Papilloma and Distinguishes It From Urothelial Carcinoma (2025)
  • A deep learning model to predict glioma recurrence using integrated genomic and clinical data (2025)
  • Promoting technological advancement and innovation in transfusion medicine: Current approaches and future directions (2025)
  • Artificial intelligence in prostate cancer (2025)
  • Harnessing Artificial Intelligence for Risk Stratification and Outcome Prediction in Urologic Cancers: A Systematic Review (2025)
  • Modular validation of lymphocyte detection and tumor and stroma segmentation models to accurately predict tumor-infiltrating lymphocytes from H&E images in metastatic lung adenocarcinoma (2025)
  • Toward Optimizing the Impact of Digital Pathology and Augmented Intelligence on Issues of Diagnosis, Grading, Staging, and Classification (2025)
  • Advancing Artificial Intelligence Integration Into the Pathology Workflow: Exploring Opportunities in Gastrointestinal Tract Biopsies (2024)
  • Scoring PD-L1 Expression in Urothelial Carcinoma: An International Multi-Institutional Study on Comparison of Manual and Artificial Intelligence Measurement Model (AIM-PD-L1) Pathology Assessments (2024)
  • A deep learning model for prediction of autism status using whole-exome sequencing data (2024)
  • Enabling the clinical application of artificial intelligence in genomics: a perspective of the AMIA Genomics and Translational Bioinformatics Workgroup (2024)
  • Applications of Artificial Intelligence in Prostate Cancer Care: A Path to Enhanced Efficiency and Outcomes (2024)
  • Harnessing artificial intelligence for prostate cancer management (2024)
  • Whole slide image features predict pathologic complete response and poor clinical outcomes in triple-negative breast cancer (2023)
  • Artificial intelligence-based multi-class histopathologic classification of kidney neoplasms (2023)
  • Using trends and outliers in managing delayed transfusions (2023)
  • Measuring the impact of a blood supply shortage using data science (2023)
  • Whole slide images as non-fungible tokens: A decentralized approach to secure, scalable data storage and access (2023)
  • Recent Advances of Deep Learning for Computational Histopathology: Principles and Applications (2022)
  • Deep Learning-Based Classification of Epithelial-Mesenchymal Transition for Predicting Response to Therapy in Clear Cell Renal Cell Carcinoma (2022)
  • Artificial Intelligence Meets Whole Slide Images: Deep Learning Model Shapes an Immune-Hot Tumor and Guides Precision Therapy in Bladder Cancer (2022)
  • A deep learning framework for automated classification of histopathological kidney whole-slide images (2022)
  • Stromal computational signatures predict upgrade to invasive carcinoma in mass-forming DCIS: A brief report of 44 cases (2022)
  • Artificial intelligence in prostate cancer: Definitions, current research, and future directions (2022)
  • LYRUS: a machine learning model for predicting the pathogenicity of missense variants (2021)
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    • Fellowships
      • Dermatopathology
      • Developmental Pediatric Pathology
      • Gastrointestinal and Liver Pathology
      • International Visiting Women's and Perinatal Pathology
      • Neuropathology
      • Genitourinary Pathology
      • Women’s Pathology (Gynecologic, Breast, and Cytopathology)
      • Two-Year Research Fellowship
    • Research
      • Fifth-Year Residency Track
      • Two-Year Research Fellowship
      • Research Centers, Institutes & Facilities
      • Research in Digital Pathology and Artificial Intelligence
    • For Applicants
      • Application Process
      • Benefits and Salary
      • Life in Rhode Island
      • Observership
      • Virtual Tour
    • Digital Pathology Library
      • Case of the Month
      • Unknown study boxes

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Research in Digital Pathology and Artificial Intelligence